Antiretroviral therapy (ART) effectively suppresses HIV viral load and controls disease, but does not fully eradicate latent HIV. Transcriptionally silent proviruses integrate in CD4+ T cells and ...

Dr. Michael Emerman, a professor in the Human Biology and Basic Sciences Divisions of Fred Hutch, has been hunting the secrets of HIV replication for decades. “There are nearly 40 million people ...

Recently, biology professor Anding Shen landed a $300, 000 grant from the National Institutes of Health (NIH) to study the role of endothelial cells in HIV infection—a project that will occupy her for ...

However, activating NF-kB also has the affect of loosening chromatin, which HIV recruits in another mechanism of latency. Therefore, upregulating the viral activator would be "good for both of these ...

Scientists have describe a class of cells that preferentially support latent infection by HIV. These cells are characterized by a surface protein called CD127 and are found in tissues such as lymph ...

An immune response that likely evolved to help fight infections appears to be the mechanism that drives human immunodeficiency virus (HIV) into a latent state, lurking in cells only to erupt anew, ...

Researchers contribute to a better understanding of HIV-1 latency: implications for the development of new therapeutic strategies. The contribution of antiretroviral drugs to the treatment of HIV-1 ...

As a part of its life cycle, the human immunodeficiency virus-1 (HIV) inserts a copy of its DNA into human immune cells. Some of these newly infected immune cells can then transition into a dormant, ...

An immune response that likely evolved to help fight infections appears to be the mechanism that drives human immunodeficiency virus (HIV) into a latent state, lurking in cells only to erupt anew, ...

Antiretroviral therapy, the standard treatment for HIV, can remove any trace of the virus from the blood, but a hidden reservoir of HIV persists in patients who are in treatment. That means patients ...