Study reveals novel mechanism that activates KEAP1 to drive NRF2 degradation, overcoming a longstanding barrier in targeting NRF2-driven tumors The article, "A covalent allosteric molecular glue ...

Epithelial ovarian cancer is the most lethal gynecological malignancy in the Western world. A major impediment for the successful treatment is the development of drug resistance. The molecular ...

(Vienna, August 9, 2022, 10:10 a.m., CEST) – Patients with metastatic non-small cell lung cancer who received a combined therapy of tremelimumab, durvalumab and chemotherapy experienced longer overall ...

This is a preview. Log in through your library . Abstract The risks of cancer and other degenerative diseases caused by reactive oxygen species and electrophiles can be reduced by the up-regulation of ...

Targeting HER2 in combination with anti-PD-1 and chemotherapy confers a significant tumor shrinkage of gastric cancer: A multi-institutional phase Ib/II trial of first-line triplet regimen ...

HOUSTON - A tumor-suppressing protein snatches up an important cancer-promoting enzyme and tags it with molecules that condemn it to destruction, a research team led by scientists at The University of ...

STK11/LKB1 revisited: A prognostic rather than predictive biomarker for immune checkpoint inhibitor in EGFR/ALKWT nonsquamous non-small cell lung cancer (NSCLC). This is an ASCO Meeting Abstract from ...

Researchers from The University of Texas MD Anderson Cancer Center have demonstrated that patients with metastatic non-squamous non-small cell lung cancer (NSCLC) harboring specific mutations in the ...

Genetic changes that help lung cancer thrive also make it vulnerable to a promising experimental drug, according to a study led by researchers from Perlmutter Cancer at NYU Langone Health, and ...

Study reveals novel mechanism that activates KEAP1 to drive NRF2 degradation, overcoming a longstanding barrier in targeting NRF2-driven tumors Preclinical data show antitumor activity and enhanced ...