A new study has uncovered how an exceptionally scarce protein can orchestrate the assembly of large-scale gene-silencing structures inside cells, and what happens when that process breaks down. The ...

Many biological functions are regulated by the switching on and off of mechanisms triggered by the matching of a keyhole ...

Single-molecule imaging shows that three CBX2 protein molecules can seed Polycomb condensates that silence genes in stem cells. The discovery reveals how rare proteins organize genome regulation and ...

A study looking at the biophysical properties of an abnormal protein driving cancer cells is giving scientists new therapeutic clues for how to treat ependymoma, the third most common childhood brain ...

Yeast, worms, and mice remodel their endoplasmic reticulum early in the aging process. The protective shift offers potential targets to extend healthy lifespan.

The immune system consists of inflammatory and regulatory T cells (Tregs) that promote or dampen immune activity, respectively. These cells react to specific antigens that specialized cells like ...

Ongoing research aims to confirm the mechanism by which ICP4 fluidizes the nucleus, which could indicate specific targets to counter viral replication.

A newly developed luciferase-based reporter can detect problems in protein translocation and disulfide bond formation in the endoplasmic reticulum (ER). Inspired by natural mechanisms found in ...

Researchers at King's College London have discovered that an immune protein best known for protecting the body against ...