Endosomal and cytosolic nucleic acid receptors sense microbial nucleic acids and initiate innate immune responses. However, in some circumstances their activation by endogenous nucleic acids can also ...

Since the discovery of the double-helical structure of DNA and postulation of the central dogma of molecular biology, stating that the flow of genetic information goes from DNA to RNA to protein, the ...

The Nucleic Acids Institute is dedicated to uncovering the chemical and biological underpinnings of nucleic acid function, and to developing innovative nucleic acid-based therapies and applications.

Thioguanosine (shown as S in the sequence) is placed at nearby, non-complementary positions within a DNA duplex. When exposed to light or mild oxidants, the modified bases react to form a disulfide ...

Nature encodes nucleic acids to assemble enormously complex and highly functional materials that form the foundation of life. To establish a similar code to construct synthetic, unnatural materials ...

At the heart of molecular biology is the study of genetic material – DNA and RNA – which serve as the fundamental blueprints for life. These nucleic acids are not only essential for understanding how ...

Whether one is elucidating biological mechanisms, correcting a faulty gene, or modulating gene expression, artificially introducing nucleic acids into cells requires an efficient and nontoxic delivery ...

Scientists developed a light-responsive artificial nucleic acid that enables reversible, controllable crosslinking within DNA, opening doors for nanomedicine, DNA nanotechnologies and drug delivery.